Ialongo and Bernardini (1) reviewed 36 investigations of pre-analytical factors related to phlebotomy issued between 1996 and 2016 (April). The largest part of studies had a cohort of healthy volunteers or outpatients, the former group with a smaller sample size. Sample size calculations for detecting a specified effect was addressed only in one manuscript. Student’s t-test and Wilcoxon’s test were often used, but many papers assessed neither bias (12) nor agreement (24).
The authors discuss recommendations for improving methodological consistency and reliable results.
- Ialongo C, Bernardini S. Preanalytical investigations of phlebotomy: methodological aspects, pitfalls and recommendations. Biochem Med (Zagreb) 2017;27:177-191.