Burke et al. (1) reviewed 125 articles from 7 journals with the highest number of basic science central nervous system animal research studies published in 2010: Brain Research, Experimental Neurology, Journal of Neurochemistry, Journal of Neurology, Journal of Neurotrauma, Neuroscience and Spinal Cord.Of the 125 articles 87 (70%) contained one or more type of data inaccuracy. The most frequent error was incorrect post-hoc t-tests (56%). The majority of parametric statistical analysis errors was from the use of one- or two-way ANOVA instead of repeated measurements ANOVA (52%).
The authors conclude that “A more rigorous approach to statistical data analysis and a more critical evaluation of studies will minimize the potential for misinterpretation of experimental results due to misapplication of data analysis procedures and programs and help ensure the continuation of promising lines of investigation in the field of CNS trauma research”.
1. Burke DA, Whittermore SR, Magnuson DS. Consequences of common data analysis inaccuracies in CNS trauma injury basic research. J Neurotrauma 2012, November 27 [Epu ahead of print]